GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs2243480 | 1 | rs7456042 | chr7:65299778 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 4.84 | 4.96E-6 | Diabetic kidney disease |
| THYM | cis | rs7849270 | 1 | rs746489 | chr9:131910093 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs2463822 | 1 | rs7481995 | chr11:62129312 | ASRGL1 | chr11:62104774-62160885:+ | 0.56 | 5.84 | 7.18E-8 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs2230307 | 1 | rs74839329 | chr1:100592057 | LRRC39 | chr1:100614413-100643800:- | 0.67 | 4.21 | 5.78E-5 | Carotid intima media thickness |
| THYM | cis | rs11723261 | 1 | rs74984113 | chr4:250522 | ZNF718 | chr4:53272-156488:+ | 0.68 | 7.3 | 8.88E-11 | Immune response to smallpox vaccine (IL-6) |
| THYM | cis | rs9894429 | 1 | rs7503679 | chr17:79583843 | TSPAN10 | chr17:79609349-79615778:+ | 0.65 | 6.74 | 1.2E-9 | Eye color traits |
| THYM | cis | rs8050907 | 1 | rs75117781 | chr16:4654204 | NMRAL1 | chr16:4511696-4526307:- | -0.5 | -5.61 | 1.96E-7 | Obesity-related traits |
| THYM | cis | rs2275426 | 1 | rs7515491 | chr1:46355079 | CCDC163P | chr1:45960581-45965646:- | -0.47 | -5.57 | 2.32E-7 | Body mass index |
| THYM | cis | rs7552404 | 1 | rs7518038 | chr1:76154430 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.17 | 6.76E-5 | Blood metabolite levels;Acylcarnitine levels |
| THYM | cis | rs7589728 | 1 | rs75181745 | chr2:88520408 | THNSL2 | chr2:88469835-88486145:+ | -0.5 | -4.23 | 5.34E-5 | Plasma clusterin levels |
| THYM | cis | rs6540731 | 1 | rs7518329 | chr1:212398533 | NEK2 | chr1:211836115-211848967:- | -0.17 | -4.33 | 3.71E-5 | Intelligence (childhood) |
| THYM | cis | rs2275426 | 1 | rs7522601 | chr1:46419021 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs4660306 | 1 | rs7522705 | chr1:45992300 | CCDC163P | chr1:45960581-45965646:- | 0.76 | 12.36 | 1.77E-21 | Homocysteine levels |
| THYM | cis | rs6684514 | 1 | rs7522948 | chr1:156275308 | CCT3 | chr1:156278752-156308195:- | -0.18 | -4.37 | 3.22E-5 | Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels |
| THYM | cis | rs7552404 | 1 | rs7524467 | chr1:76194054 | ACADM | chr1:76190043-76229353:+ | 0.3 | 4.24 | 5.21E-5 | Blood metabolite levels;Acylcarnitine levels |